Dubin-Johnson syndrome is associated with defective transport of bilirubin into which site?

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Multiple Choice

Dubin-Johnson syndrome is associated with defective transport of bilirubin into which site?

The main concept here is the excretion of conjugated bilirubin from hepatocytes into the bile drainage system. In Dubin-Johnson syndrome, a defect in the canalicular transporter (MRP2/ABCC2) impairs the export of conjugated bilirubin into the bile canaliculi. Because this export step is faulty, conjugated bilirubin accumulates in the hepatocytes and spills back into the bloodstream, causing conjugated hyperbilirubinemia. The critical site that fails to receive bilirubin is the bile canaliculi, not the cytosol, the gallbladder, or the blood plasma.

The main concept here is the excretion of conjugated bilirubin from hepatocytes into the bile drainage system. In Dubin-Johnson syndrome, a defect in the canalicular transporter (MRP2/ABCC2) impairs the export of conjugated bilirubin into the bile canaliculi. Because this export step is faulty, conjugated bilirubin accumulates in the hepatocytes and spills back into the bloodstream, causing conjugated hyperbilirubinemia. The critical site that fails to receive bilirubin is the bile canaliculi, not the cytosol, the gallbladder, or the blood plasma.

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