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Multiple Choice

Hyponatremia due to increased sodium loss EXCEPT

Hyponatremia due to increased sodium loss happens when the kidneys waste sodium, so the serum sodium falls because Na+ is lost in urine rather than because too much water is retained. Diuretic use promotes natriuresis by blocking Na+ reabsorption in the renal tubules, directly causing sodium loss and hyponatremia. Hypoadrenalism reduces aldosterone, leading to decreased Na+ reabsorption and increased urinary Na+ loss, also producing hyponatremia. Potassium deficiency often accompanies diuretic use or mineralocorticoid effects that promote sodium loss, so it fits the pattern of Na+ loss–related hyponatremia. Renal failure, by contrast, typically causes hyponatremia mainly through dilutional effects from impaired free-water excretion rather than direct loss of sodium in the urine, making it the exception.

Hyponatremia due to increased sodium loss happens when the kidneys waste sodium, so the serum sodium falls because Na+ is lost in urine rather than because too much water is retained. Diuretic use promotes natriuresis by blocking Na+ reabsorption in the renal tubules, directly causing sodium loss and hyponatremia. Hypoadrenalism reduces aldosterone, leading to decreased Na+ reabsorption and increased urinary Na+ loss, also producing hyponatremia. Potassium deficiency often accompanies diuretic use or mineralocorticoid effects that promote sodium loss, so it fits the pattern of Na+ loss–related hyponatremia. Renal failure, by contrast, typically causes hyponatremia mainly through dilutional effects from impaired free-water excretion rather than direct loss of sodium in the urine, making it the exception.