In hypothyroidism, cholesterol and triglycerides are typically?

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Thyroid hormones normally boost lipid clearance and metabolism, so when they are low, lipid handling slows. Specifically, reduced thyroid activity lowers LDL receptor expression and function, leading to decreased clearance of LDL cholesterol and a rise in total cholesterol. It also decreases lipoprotein lipase activity, slowing the breakdown of triglyceride-rich lipoproteins and increasing triglycerides. The net effect is that both cholesterol and triglycerides are typically elevated in hypothyroidism, and these abnormalities often improve with thyroid hormone replacement.