Major structural protein in VLDL and LDL:

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Multiple Choice

Major structural protein in VLDL and LDL:

Apolipoprotein B-100 is the major structural protein of VLDL and LDL. It acts as the scaffold that backs the particle with a lipid core, enabling assembly and stability of the lipoprotein as it circulates. In the liver, apoB-100 is synthesized and used to form VLDL; after lipolysis and remodeling, VLDL-derived particles become IDL and then LDL, with apoB-100 remaining as the key surface protein throughout. Importantly, apoB-100 also serves as the ligand for hepatic LDL receptors, allowing clearance of LDL from the bloodstream. In contrast, ApoB-48 is the intestinal form of apoB and is the main protein of chylomicrons, not VLDL/LDL. ApoA-1 and ApoA-2 are the primary apolipoproteins of HDL and participate in reverse cholesterol transport and LCAT activation, not the structural framework of VLDL or LDL.

Apolipoprotein B-100 is the major structural protein of VLDL and LDL. It acts as the scaffold that backs the particle with a lipid core, enabling assembly and stability of the lipoprotein as it circulates. In the liver, apoB-100 is synthesized and used to form VLDL; after lipolysis and remodeling, VLDL-derived particles become IDL and then LDL, with apoB-100 remaining as the key surface protein throughout. Importantly, apoB-100 also serves as the ligand for hepatic LDL receptors, allowing clearance of LDL from the bloodstream. In contrast, ApoB-48 is the intestinal form of apoB and is the main protein of chylomicrons, not VLDL/LDL. ApoA-1 and ApoA-2 are the primary apolipoproteins of HDL and participate in reverse cholesterol transport and LCAT activation, not the structural framework of VLDL or LDL.

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