Which dye is most specific for measurement of albumin?

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Dye-binding assays measure albumin by how strongly a dye binds to it, so the most reliable measurement comes from a dye that binds albumin with the least interference from other proteins. Bromcresol Green has the highest specificity for albumin among these dyes because its interaction with the albumin molecule is strong and comparatively selective, resulting in a color change that predominantly reflects albumin concentration. The other dyes tend to bind to other serum proteins or are more susceptible to interference from non-albumin components, which can skew the measurement. Therefore, Bromcresol Green provides the most albumin-specific readout in this type of assay.