Which of the following combinations correctly identifies the condition with apolipoprotein A-I deficiency?

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Multiple Choice

Which of the following combinations correctly identifies the condition with apolipoprotein A-I deficiency?

Apolipoprotein A-I is the main protein component of HDL and is essential for initiating reverse cholesterol transport. It acts as a cofactor for LCAT, helping HDL particles mature and carry cholesterol away from tissues to the liver. When Apo A-I is deficient, HDL levels fall dramatically, producing hypoalphalipoproteinemia. The option that specifically names Apoprotein A-I deficiency directly identifies this scenario, making it the best choice. The other options describe deficiencies or roles related to other apolipoproteins (for example, Apo C-II deficiency disrupts activation of lipoprotein lipase and raises triglycerides; Apo B-100 deficiency affects LDL/VLDL production) and do not describe Apo A-I deficiency.

Apolipoprotein A-I is the main protein component of HDL and is essential for initiating reverse cholesterol transport. It acts as a cofactor for LCAT, helping HDL particles mature and carry cholesterol away from tissues to the liver. When Apo A-I is deficient, HDL levels fall dramatically, producing hypoalphalipoproteinemia. The option that specifically names Apoprotein A-I deficiency directly identifies this scenario, making it the best choice. The other options describe deficiencies or roles related to other apolipoproteins (for example, Apo C-II deficiency disrupts activation of lipoprotein lipase and raises triglycerides; Apo B-100 deficiency affects LDL/VLDL production) and do not describe Apo A-I deficiency.

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