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Multiple Choice

Which test requires prechilled EDTA for sample collection?

ACTH is highly unstable in blood and rapidly degrades after collection unless the specimen is kept cold and protected from proteolysis. Using a prechilled EDTA tube on ice, and then promptly separating plasma, preserves ACTH for accurate immunoassay measurement. The other tests listed are not as labile and do not require this extreme preanalytical handling.

ACTH is highly unstable in blood and rapidly degrades after collection unless the specimen is kept cold and protected from proteolysis. Using a prechilled EDTA tube on ice, and then promptly separating plasma, preserves ACTH for accurate immunoassay measurement. The other tests listed are not as labile and do not require this extreme preanalytical handling.